Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages
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چکیده
منابع مشابه
Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages.
Tat stimulates human immunodeficiency virus type 1 (HIV-1) transcription elongation through recognition of the transactivation response (TAR) RNA stem-loop structure at the 5' end of nascent viral transcripts. Recently, a human transcription elongation factor P-TEFb, consisting of CDK9 kinase, cyclin T and other associated factors, has been shown to interact with Tat to restore Tat activation i...
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Recent studies suggest that the human immunodeficiency virus transactivator, Tat, increases expression of viral genes primarily by enhancing the efficiency of transcriptional elongation. The degree to which Tat influences elongation may depend on the rate of transcriptional initiation. Current models in which Tat interacts with the transcription complex suggest directions for future studies.
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1998
ISSN: 1460-2075
DOI: 10.1093/emboj/17.13.3681